Sanyal P K, Gupta S C
Biotechnology Laboratory, National Dairy Development Board, Gujarat, India.
Vet Res Commun. 1996;20(5):461-8. doi: 10.1007/BF00419183.
A study was conducted on the pharmacokinetics and therapeutic efficacy of triclabendazole at three low dose rates of 0.5, 1.0 and 1.5 mg/kg body weight in buffaloes experimentally infected with Fasciola gigantica. The pharmacokinetics were compared with the effects of a single intraruminal dose at 24.0 mg/kg body weight in uninfected buffaloes. At all three dose rates, an equilibrium between the absorption of triclabendazole and the disposition of its metabolites was observed by days 3 and 4 and remained almost unchanged thereafter. Continuous daily dosing at 1.5 mg/kg body weight proved to be efficacious against liver fluke infection in buffaloes.
在实验感染大片吸虫的水牛中，开展了一项关于三氯苯达唑在0.5、1.0和1.5毫克/千克体重这三种低剂量率下的药代动力学及治疗效果的研究。将这些药代动力学与未感染水牛单次瘤胃内注射24.0毫克/千克体重的效果进行了比较。在所有三种剂量率下，到第3天和第4天时观察到三氯苯达唑的吸收与其代谢物的处置之间达到平衡，此后几乎保持不变。结果证明，以1.5毫克/千克体重连续每日给药对水牛肝吸虫感染有效。
