Saito N
Nihon Rinsho. 1996 Jan;54(1):59-66.
It is known that the peroxidation of LDL is a trigger for developing arteriosclerosis. The oxidized LDL is produced by either oxidative stress or a few oxidant. Selenium decreased in serum and some organs of stroke-prone spontaneously hypertensive rats (SHRSP), which is a cofactor of glutamine peroxidase. Serum magnesium decreased in patients with diabetes mellitus, with ischemic heart disease, with essential hypertension and with cerebral vascular lesions. Calcium to magnesium ratio was higher in some organs of SHRSP as compared to Wistar Kyoto rats (WKY). These changes accelerated vascular lesions in SHRSP.
已知低密度脂蛋白（LDL）的过氧化是引发动脉硬化的一个因素。氧化型LDL是由氧化应激或一些氧化剂产生的。谷胱甘肽过氧化物酶的辅因子硒，在易发生中风的自发性高血压大鼠（SHRSP）的血清和一些器官中含量降低。糖尿病、缺血性心脏病、原发性高血压和脑血管病变患者的血清镁含量降低。与Wistar Kyoto大鼠（WKY）相比，SHRSP某些器官中的钙镁比更高。这些变化加速了SHRSP的血管病变。
