Ito Y, Fujita T
4th Department of Medicine, University of Tokyo.
Nihon Rinsho. 1996 Jan;54(1):106-10.
Essential trace elements such as copper, zinc and selenium participate in various enzyme reactions necessary for antioxidant defense system of cells. It is not clear whether metabolism of these trace elements and related enzymes are specifically altered in hypertensive animals or humans. As endothelium-derived nitric oxide is inactivated by free radicals, oxidative stress is known to be involved in the pathogenesis of various vascular diseases including certain type(s) of arterial hypertension. The present review focuses on biological activity of endothelium-derived nitric oxide and trace elements and discusses the pathophysiological implications of trace elements for hypertension.
铜、锌和硒等必需微量元素参与细胞抗氧化防御系统所需的各种酶反应。目前尚不清楚这些微量元素和相关酶的代谢在高血压动物或人类中是否会发生特异性改变。由于内皮源性一氧化氮会被自由基灭活，氧化应激被认为参与了包括某些类型动脉高血压在内的各种血管疾病的发病机制。本综述重点关注内皮源性一氧化氮和微量元素的生物学活性，并讨论微量元素对高血压的病理生理学意义。
