Corder R, Carrier M, Khan N, Klemm P, Vane J R
William Harvey Research Institute, St. Bartholomew's Hospital Medical College, London, England.
J Cardiovasc Pharmacol. 1995;26 Suppl 3:S56-8.
The action of cytokines on the endothelium is a pivotal event in a number of vascular pathologies and inflammatory conditions. Here we have tested the effect of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta, and IL-2 on endothelial-1 (ET-1) release from cultured bovine aortic endothelial cells. TNF-alpha and IL-1 beta caused concentration-dependent increases in ET-1 release. IL-2 up to concentrations of 100 ng/ml did not stimulate ET-1 release. The induction of ET-1 synthesis by cytokines may be of underlying importance in the endothelial cell dysfunction observed in a number of vascular diseases.
细胞因子对内皮细胞的作用是许多血管病变和炎症状态中的关键事件。在此，我们测试了肿瘤坏死因子-α（TNF-α）、白细胞介素（IL）-1β和IL-2对培养的牛主动脉内皮细胞释放内皮素-1（ET-1）的影响。TNF-α和IL-1β导致ET-1释放呈浓度依赖性增加。浓度高达100 ng/ml的IL-2未刺激ET-1释放。细胞因子诱导ET-1合成可能在许多血管疾病中观察到的内皮细胞功能障碍中具有潜在重要性。
