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[癫痫发作与生物节律的相互作用]

[Interaction of epileptic seizures and biological rhythms].

作者信息

Bülau P, Clarenbach P

机构信息

Westerwaldklinik Waldbreitbach, Deutschland.

出版信息

Wien Med Wochenschr. 1995;145(17-18):448-51.

PMID:8588362
Abstract

Circadian modulation of seizure threshold is subjected to a multitude of periodical, aperiodical and stochastical influences. Epilepsies on the other hand influence the biological rhythms themselves. Epileptic seizures are activated during transient sleep stages. Nocturnal seizures lead to severe sleep disorders and therefore to hypersomnia. Partial and generalized epilepsies have a different sleep profil even without seizure manifestation. Finally antiepileptic drugs may interfere with circadian rhythms. Knowing the chronobiological context a differentiation of epileptic seizures from nonepileptic parasomnias may succeed more easily. To ensure the appropriate diagnostical proceeding multichannel EEG should be used in every polysomnography with neurological topics.

摘要

癫痫发作阈值的昼夜节律调节受到多种周期性、非周期性和随机性影响。另一方面,癫痫会影响生物节律本身。癫痫发作在短暂睡眠阶段被激活。夜间发作会导致严重的睡眠障碍,进而导致嗜睡。即使没有癫痫发作表现,部分性和全身性癫痫也有不同的睡眠特征。最后,抗癫痫药物可能会干扰昼夜节律。了解时间生物学背景后,区分癫痫发作和非癫痫性异态睡眠可能会更容易成功。为确保适当的诊断程序,在每一项涉及神经学问题的多导睡眠图检查中都应使用多通道脑电图。

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