Linder T E, Zwicky S, Brändle P
Department of Otorhinolaryngology, University Hospital Zürich, Switzerland.
Am J Otol. 1995 Sep;16(5):653-7.
Although experimental data confirm the presence of ototoxicity due to topical ear drops, the clinical relevance still remains debatable. Only few case reports document sensorineural hearing loss (SNHL) attributable to ototopical preparations in patients with chronic otitis media. A careful review of 134 patients charts evaluated between 1953 and 1995 for possible antibiotic related ototoxicity revealed two patients with bilateral profound SNHL attributable to excessive administration of framycetin- and polymyxin-containing ear drops in the presence of tympanic membrane perforation. Although ototopical preparations are widely used, they rarely induce SNHL. The authors emphasize patient education, application of topical ear drops using soaked gauze strips, and documentation of the patients hearing status at the beginning of the treatment regimen.
尽管实验数据证实局部用耳滴剂存在耳毒性，但临床相关性仍存在争议。仅有少数病例报告记录了慢性中耳炎患者因耳局部用药制剂导致的感音神经性听力损失（SNHL）。对1953年至1995年间评估的134例患者病历进行仔细回顾，以寻找可能与抗生素相关的耳毒性，结果发现两名患者因在鼓膜穿孔情况下过量使用含新霉素和多粘菌素的耳滴剂而出现双侧严重SNHL。尽管耳局部用药制剂被广泛使用，但它们很少引起SNHL。作者强调患者教育、使用浸泡过的纱布条应用局部用耳滴剂，以及在治疗方案开始时记录患者的听力状况。
