Rakover Y, Keywan K, Rosen G
Department of Otorhinolaryngology, Central Emek Hospital, Afula, Israel.
J Otolaryngol. 1997 Jun;26(3):194-6.
Topical application of ear drops containing ototoxic antibiotics is commonly used for treatment of middle ear diseases. Because of their ototoxic potential, we evaluated the safety of these ear drops in clinical use.
The study included 446 children who underwent myringotomy and the insertion of tympanostomy tubes. Three hundred and fifty-eight received preventive treatment after the operation with polymyxin B-neomycin-dexamethasone ear drops for 2 weeks; 88 did not receive any ear drops. Audiometric tests were performed before the operation and up to 3 months following it.
All 446 children had a normal sensorineural hearing threshold before and after the operation. There was no sensorineural hearing loss in the group that was treated with ear drops.
Our experience leads us to believe that topical ear drops containing ototoxic antibiotics are clinically safe to use for a short period of time.
含有耳毒性抗生素的滴耳剂局部应用常用于治疗中耳疾病。鉴于其潜在的耳毒性，我们评估了这些滴耳剂在临床使用中的安全性。
该研究纳入了446例行鼓膜切开术并插入鼓膜造孔管的儿童。358例在术后接受了多粘菌素B-新霉素-地塞米松滴耳剂预防性治疗，为期2周；88例未接受任何滴耳剂治疗。术前及术后长达3个月进行听力测试。
所有446例儿童术前和术后的感音神经性听力阈值均正常。接受滴耳剂治疗的组中未出现感音神经性听力损失。
我们的经验使我们相信，含有耳毒性抗生素的局部滴耳剂在临床上短期使用是安全的。
