[人免疫缺陷病毒2型跨膜糖蛋白gp41的环状十一肽序列593 - 603的乙酰胺合成]
[Synthesis of an ethylamide of the cyclic undecapeptide sequence 593-603 of transmembrane glycoprotein gp41 of the human immunodeficiency virus type 2].
作者信息
Sidorova M V, Kudriavtseva E V, Molokoedov A S, Ovchinnikov M V, Bespalova Zh D
出版信息
Bioorg Khim. 1995 Sep;21(9):675-83.
PMID:8588812
Abstract
Ethylamide of cyclic disulfide of peptide HIV-2 antigen corresponding to 593-603 sequence of gp41 protein was synthesized by conventional methods of peptide chemistry in solution. The absence of racemization during fragment condensation was shown. Different methods of disulfide bond formation were compared.
摘要
采用溶液中肽化学的常规方法合成了与gp41蛋白593 - 603序列相对应的肽HIV-2抗原环状二硫化物的乙酰胺。结果表明在片段缩合过程中没有消旋现象。比较了形成二硫键的不同方法。
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