Kudriavtseva E V, Sidorova M V, Ovchinnikov M V, Bespalova Zh D, Bushuev V N, Evstigneeva R P
Bioorg Khim. 1996 May;22(5):370-5.
Removal of Acm-protecting group from thiol functional groups of Cys residues with simultaneous disulfide bridge formation by iodine in acetic acid was studied in the course of the synthesis of a peptide fragment corresponding to 593-603 sequence of HIV-2 gp41 glycoprotein. The excess iodine influence on the cyclization process was investigated. By-products of the oxidative disulfide formation were isolated, and their structures were elucidated by means of amino acid and elemental analyses, mass spectrometry, NMR, and UV-spectroscopy.
在合成对应于HIV-2 gp41糖蛋白593 - 603序列的肽片段过程中，研究了在乙酸中用碘从半胱氨酸残基的硫醇官能团上去除Acm保护基团并同时形成二硫键的情况。研究了过量碘对环化过程的影响。分离出氧化二硫形成的副产物，并通过氨基酸分析、元素分析、质谱、核磁共振和紫外光谱对其结构进行了阐明。
