Schüssler P, Pötters E, Winnen R, Bottke W, Kunz W
Institut für Genetik and Biologisch-Medizinisches Forschungszentrum, Heinrich-Heine-Universität, Düsseldorf, Germany.
Mol Reprod Dev. 1995 Jul;41(3):325-30. doi: 10.1002/mrd.1080410307.
Schistosoma mansoni possesses two isoforms of the iron storage protein ferritin, Fer1 and Fer2. At the mRNA level as well as at the protein level, Fer1 is much more abundant than Fer2; females contain an about 15-fold excess of Fer1 compared with males. In contrast, nearly equal amounts of Fer2 occur in both sexes. By electron microscopy we identified ferritin as a component of electron dense membrane-bound bodies in cells of the vitellarium. The mode of formation of these inclusions (as inferred from electron microscopy) and the abundance of phospholipid multilayered membranes suggest that these bodies are of a lysosomal nature. Here we interpret these ferritin-containing inclusions as protein yolk platelets. To date, most of the literature does not contain any hints of the existence of protein yolk in trematodes. The possible function of ferritin in embryonic development is discussed.
曼氏血吸虫拥有两种铁储存蛋白铁蛋白的异构体，即Fer1和Fer2。在mRNA水平以及蛋白质水平上，Fer1的含量都比Fer2丰富得多；雌性体内Fer1的含量比雄性多约15倍。相比之下，两性体内Fer2的含量几乎相等。通过电子显微镜，我们确定铁蛋白是卵黄腺细胞中电子致密的膜结合体的一个组成部分。这些内含物的形成方式（从电子显微镜推断）以及磷脂多层膜的丰富程度表明这些物体具有溶酶体性质。在这里，我们将这些含铁蛋白的内含物解释为蛋白质卵黄小板。迄今为止，大多数文献都没有任何关于吸虫中存在蛋白质卵黄的线索。文中讨论了铁蛋白在胚胎发育中的可能功能。
