努南综合征合并急性白血病。

Noonan's syndrome in association with acute leukemia.

作者信息

Johannes J M, Garcia E R, De Vaan G A, Weening R S

机构信息

Department of Pediatrics, Emma Children's Hospital, Academic Medical Center, Amsterdam, The Netherlands.

出版信息

Pediatr Hematol Oncol. 1995 Nov-Dec;12(6):571-5. doi: 10.3109/08880019509030771.

DOI:10.3109/08880019509030771

PMID:8589002

Abstract

Noonan's syndrome (NS) is a syndrome with multiple congenital anomalies, characterized by craniofacial anomalies, congenital heart disease, skeletal and genital abnormalities, and mild mental retardation. Chromosomal abnormalities have been found in only a few cases. The combination of NS and acute leukemia has been reported in only three cases. Two additional cases are described here.

摘要

努南综合征（NS）是一种伴有多种先天性异常的综合征，其特征为颅面异常、先天性心脏病、骨骼和生殖器异常以及轻度智力发育迟缓。仅在少数病例中发现了染色体异常。NS与急性白血病并存的情况仅报道过3例。本文描述另外2例。