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Inherited polymorphism of guinea pig factor B and C4: evidence for genetic linkage between the C4 and Bf loci.

作者信息

Bitter-Suermann D, Krönke M, Brade V, Hadding U

出版信息

J Immunol. 1977 May;118(5):1822-6.

PMID:858918
Abstract

An inherited structural polymorphism of the guinea pig complement protein C4 and of factor B of the alternative pathway was demonstrated by use of high voltage agarose electrophoresis combined with a subsequent immunofixation technique. No polymorphism of guinea pig C3 could be shown. Three common allelic genes were proven to code for C4-S, C4-S1, and C4-F, respectively. Two common allelic genes are responsible for the Bf-F and Bf-S phenotype expression. A strong linkage disequilibrium between both C4 and Bf was demonstrated.

摘要

相似文献

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引用本文的文献

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