Wyatt R J, Wang C, Hudson E C, Jones R M, Noah P W, Rosenberg E W
Department of Pediatrics, University of Tennessee, Memphis.
Acta Derm Venereol Suppl (Stockh). 1989;146:211-3.
Phenotype frequencies for the complement proteins Bf (factor B), C4A and C4B were performed in a sample of 49 Caucasian patients with psoriasis followed in Memphis, Tennessee. The genes for these proteins are located in the major histocompatibility complex between the HLA-B and HLA-DR loci. Bf phenotype frequency did not differ significantly for the patients as compared to regional controls. The C4A6 allele was present in 26.6% of the patients as compared to 5.4% of the controls, p less than 0.001, relative risk = 4.93. The C4A6 allele is known to be in linkage disequilibrium with the HLA B17 allele and produces a functionally defective gene product. The role, if any, of C4*A6 in the pathogenesis of psoriasis is uncertain.
在田纳西州孟菲斯市随访的49例白种人银屑病患者样本中，对补体蛋白Bf（B因子）、C4A和C4B的表型频率进行了检测。这些蛋白的基因位于主要组织相容性复合体中HLA - B和HLA - DR基因座之间。与区域对照相比，患者的Bf表型频率无显著差异。患者中C4A6等位基因的出现频率为26.6%，而对照中为5.4%，p小于0.001，相对风险 = 4.93。已知C4A6等位基因与HLA B17等位基因处于连锁不平衡状态，并产生功能缺陷的基因产物。C4*A6在银屑病发病机制中的作用（如果有）尚不确定。
