Stirling Y
MRC Epidemiology and Medical Care Unit, Wolfson Institute of Preventive Medicine, Medical College of St Bartholomew's Hospital, London, UK.
Blood Coagul Fibrinolysis. 1995 Jul;6(5):361-73. doi: 10.1097/00001721-199507000-00001.
Dicoumarol was found to be the causative agent of a haemorrhagic disease in cattle following the ingestion of spoiled sweet clover. Vitamin K deficiency in chickens caused bleeding. Dicoumarol was later determined to be a vitamin K antagonist. A more potent form of the drug was produced synthetically and, following its initial use as rat poison, was recognized as a potential anti-thrombotic treatment in humans. The mode of action of a coumarin derivative (i.e. warfarin) is described. The overall effect of high-dose and low-dose warfarin and the possibility of a transient state of hypercoagulability on the introduction and withdrawal of treatment is considered.
双香豆素被发现是牛食用变质甜苜蓿后发生出血性疾病的致病因子。鸡的维生素K缺乏会导致出血。双香豆素后来被确定为一种维生素K拮抗剂。一种药效更强的该类药物是通过合成生产的，最初用作杀鼠剂，后来被认为是一种潜在的人类抗血栓治疗药物。文中描述了一种香豆素衍生物（即华法林）的作用方式。考虑了高剂量和低剂量华法林的总体效果以及在治疗开始和停药时出现短暂高凝状态的可能性。
