APC抵抗与心肌梗死无关联。

No association of APC resistance with myocardial infarction.

作者信息

Demarmels Biasiutti F, Merlo C, Furlan M, Sulzer I, Binder B R, Lämmle B

机构信息

Central Haematology Laboratory, Inselspital, University Hospital of Bern, Switzerland.

出版信息

Blood Coagul Fibrinolysis. 1995 Jul;6(5):456-9. doi: 10.1097/00001721-199507000-00013.

DOI:10.1097/00001721-199507000-00013

PMID:8589213

Abstract

Resistance to activated protein C (APC resistance) due to the factor V mutation 506 Arg-->Gln (factor V Leiden) is the most prevalent inherited risk factor for venous thromboembolism. Its association with arterial thromboembolic disease, however, is still controversial. In the present study we found no difference between the prevalence of APC resistance (assessed by the ratio of the aPTT with and without added APC) in 134 non-anticoagulated survivors of myocardial infarction and that in 100 controls of similar age and sex distribution (2.2% and 2.0%, respectively). Patients showed a significantly higher median value for the aPTT ratio than controls (2.85 and 2.66, respectively), a fact we could not explain by our data.

摘要

由于凝血因子V发生506位精氨酸突变为谷氨酰胺（凝血因子V莱顿突变）而导致的对活化蛋白C的抵抗（APC抵抗），是静脉血栓栓塞最常见的遗传性危险因素。然而，其与动脉血栓栓塞性疾病的关联仍存在争议。在本研究中，我们发现134例非抗凝治疗的心肌梗死幸存者中APC抵抗的患病率（通过加入和未加入APC时的活化部分凝血活酶时间比值评估）与100例年龄和性别分布相似的对照组相比无差异（分别为2.2%和2.0%）。患者的活化部分凝血活酶时间比值中位数显著高于对照组（分别为2.85和2.66），我们的数据无法解释这一现象。