Kuroda H, Suga H
Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
ASAIO J. 1995 Oct-Dec;41(4):855-62.
The authors produced an acute canine heart failure model by injecting microspheres (phi 15.5 +/- 0.1 mm, 5 x 10(5)) into the left coronary artery, and characterized the model in terms of the pressure-volume relationship obtained by the conductance catheter method. Cardiodynamics of the microsphere injection group (M group: n = 10) and control group (C group: n = 12) were studied with 1) heart rate, 2) aortic pressure, 3) cardiac output (CO), 4) maximal ventricular elastance, 5) effective arterial elastance/maximal ventricular elastance, and 6) external work/pressure-volume area efficiency. With microsphere injection, CO and external work/pressure-volume area efficiency significantly decreased. With administration of dobutamine (5 mg/kg/min), CO and maximal ventricular elastance recovered to normal and aortic pressure became higher than normal. These changes in heart rate, aortic pressure, CO, maximal ventricular elastance, and external work/pressure-volume area efficiency in the M group were comparable in percentage to those in the C groups. Cardiodynamics of this heart failure model generally were stable for 3 hrs after microsphere injection. The authors concluded that this model would be an excellent acute heart failure model for investigating hemodynamic effects of circulatory assist devices.
作者通过向左冠状动脉注射微球（直径15.5±0.1毫米，5×10⁵个）建立了急性犬心力衰竭模型，并根据通过电导导管法获得的压力-容积关系对该模型进行了表征。用以下指标研究微球注射组（M组：n = 10）和对照组（C组：n = 12）的心脏动力学：1）心率，2）主动脉压，3）心输出量（CO），4）最大心室弹性，5）有效动脉弹性/最大心室弹性，以及6）外功/压力-容积面积效率。注射微球后，心输出量和外功/压力-容积面积效率显著降低。给予多巴酚丁胺（5毫克/千克/分钟）后，心输出量和最大心室弹性恢复正常，主动脉压高于正常。M组中心率、主动脉压、心输出量、最大心室弹性和外功/压力-容积面积效率的这些变化在百分比上与C组相当。该心力衰竭模型的心脏动力学在微球注射后通常在3小时内保持稳定。作者得出结论，该模型将是用于研究循环辅助装置血流动力学效应的优秀急性心力衰竭模型。
