Happle R
Department of Dermatology, Philipp University of Marburg, Germany.
Dermatology. 1995;191(1):1-5. doi: 10.1159/000246468.
From the study of standard textbooks of dermatology, no comprehensive understanding of the word nevus can be derived. The purpose of this article is to formulate a workable definition. As a first step, various definitions proposed by previous authors are reviewed. Their inconsistency appears to be mainly due to the fact that the term nevus is used to denote both neoplastic and nonneoplastic, congenital and acquired as well as hereditary and nonhereditary skin lesions. Taking this difficulty into account, the author suggests, as a unifying concept, the new category of genetic mosaicism. The following definition is proposed: 'Nevi are visible, circumscribed, long-lasting lesions of the skin or the neighboring mucosa, reflecting genetic mosaicism. With the exception of melanocytic nevi, they do not show neoplastic growth. They never show malignant neoplasia.'--For several types of nevi the concept of genetic mosaicism has already been confirmed at the cellular level. Future cytogenetic and molecular studies should show whether the proposed definition is valid for all other types of nevi and thus generally acceptable.
从对皮肤病学标准教科书的研究中，无法对“痣”这个词有全面的理解。本文的目的是制定一个可行的定义。第一步，回顾先前作者提出的各种定义。它们的不一致似乎主要是因为“痣”这个术语既用于表示肿瘤性和非肿瘤性、先天性和后天性以及遗传性和非遗传性皮肤病变。考虑到这一困难，作者提出了遗传镶嵌现象这一新类别作为统一概念。现提出以下定义：“痣是皮肤或邻近黏膜可见的、界限清楚的、持久的病变，反映遗传镶嵌现象。除黑素细胞痣外，它们不显示肿瘤性生长。它们从不显示恶性肿瘤。”——对于几种类型的痣，遗传镶嵌现象的概念已在细胞水平得到证实。未来的细胞遗传学和分子研究应表明所提出的定义是否对所有其他类型的痣都有效，从而是否普遍可接受。
