Sparrow L E, English D R, Heenan P J, Dawkins H J, Taran J
Department of Pathology, Queen Elizabeth II Medical Centre, Nedlands, Western Australia.
Melanoma Res. 1995 Dec;5(6):387-92. doi: 10.1097/00008390-199512000-00001.
Metastasis by thin melanomas is uncommon and unpredictable. In order to assess the prognostic value of p53 expression, p53 immunohistochemical staining was evaluated in 20 thin melanomas with documented metastasis and in 20 control tumours which failed to metastasize. Tumours selected were less than 1 mm thick and were individually matched for tumour thickness, date of excision and patient age and sex. The relative risk of metastasis given p53 overexpression was 1.5 (95% confidence interval 0.4-5.3; p = 0.53). Further quantitative analysis for p53 between the two groups did not demonstrate a significant difference (p = 0.08). These results are consistent with there being no association between p53 overexpression in thin melanomas and risk of metastasis, however, the sample size was small, and the existence of such an association cannot be ruled out with confidence. For the 20 thin melanomas which metastasized, there was no association between the proportion of cells positive for p53 and length of the relapse-free period (correlation coefficient = 0.02, p = 0.94).
薄型黑色素瘤的转移并不常见且难以预测。为了评估p53表达的预后价值，对20例有转移记录的薄型黑色素瘤和20例未发生转移的对照肿瘤进行了p53免疫组化染色评估。所选肿瘤厚度小于1毫米，并根据肿瘤厚度、切除日期以及患者年龄和性别进行了个体匹配。p53过表达时转移的相对风险为1.5（95%置信区间0.4 - 5.3；p = 0.53）。两组之间对p53的进一步定量分析未显示出显著差异（p = 0.08）。这些结果与薄型黑色素瘤中p53过表达与转移风险之间不存在关联一致，然而，样本量较小，不能完全排除这种关联的存在。对于20例发生转移的薄型黑色素瘤，p53阳性细胞比例与无复发生存期长度之间无关联（相关系数 = 0.02，p = 0.94）。
