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Human skeletal muscle mitochondria in aging: lack of detectable morphological and enzymic defects.

作者信息

Zucchini C, Pugnaloni A, Pallotti F, Solmi R, Crimi M, Castaldini C, Biagini G, Lenaz G

机构信息

Istituto di Morfologia Umana Normale, Università di Ancona.

出版信息

Biochem Mol Biol Int. 1995 Nov;37(4):607-16.

PMID:8589633
Abstract

We have investigated structural and functional properties of skeletal muscle mitochondria obtained from biopsies from young and old individuals. The morphometric analysis of muscle sections revealed a tendency to an increase of total area, numerical density and volume density of mitochondria in the aged. The enzymatic activities of NADH-Coenzyme Q reductase, succinate cytochrome c reductase, ubiquinol-cytochrome c reductase exhibited a high variability of specific activities without any correlation with age. Expression of the values as enzyme turnovers reduced the variability but was unable to reveal any age-dependent modification.

摘要

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