Kao C C, Chang L W, Bloodworth J M
J Neurosurg. 1977 Jun;46(6):757-66. doi: 10.3171/jns.1977.46.6.0757.
Cavitation adjacent to transection of spinal cords can be successfully eliminated by a second operation 1 week after the initial spinal cord transection. The second operation consists of removal of the necrotic spinal cord tissue, thus producing a gap. Segments of autogenous sciatic nerve are inserted into the gap between the spinal cord stumps. If the spinal cord is injured by retransection at the second operation, cavitation again occurs in the spinal cord stumps resulting in separation of the nerve grafts from the spinal cord. The results of the present experiments support the concept that lysosomal spinal cord autotomy, which causes spinal cord cavitation, is a self-limiting process and that once the spinal cord has completed the autotomy, the process will not occur again unless the spinal cord is agiain traumatized.
脊髓横断附近的空洞可在初次脊髓横断1周后通过二次手术成功消除。二次手术包括切除坏死的脊髓组织，从而形成一个间隙。将自体坐骨神经段插入脊髓残端之间的间隙。如果在二次手术时脊髓因再次横断而受损，脊髓残端会再次出现空洞，导致神经移植物与脊髓分离。本实验结果支持以下概念：导致脊髓空洞形成的溶酶体性脊髓自切是一个自我限制的过程，并且一旦脊髓完成自切，除非脊髓再次受到创伤，该过程不会再次发生。
