注定要激活：细胞周期蛋白与CDK2结合的构象后果。
Bound to activate: conformational consequences of cyclin binding to CDK2.
作者信息
Radzio-Andzelm E, Lew J, Taylor S
机构信息
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla 92093, USA.
出版信息
Structure. 1995 Nov 15;3(11):1135-41. doi: 10.1016/s0969-2126(01)00249-0.
PMID:8591024
Abstract
The cyclin-dependent kinases (CDKs) are among the most highly regulated enzymes in the protein-kinase family. The crystal structures of cyclin A and the CDK2-cyclin A complex spectacularly reveal the atomic basis for regulation of these enzymes and provide a template for understanding the function and regulation of other members of the CDK family.
摘要
细胞周期蛋白依赖性激酶（CDKs）是蛋白激酶家族中受调控最为严格的酶类之一。细胞周期蛋白A以及CDK2-细胞周期蛋白A复合物的晶体结构惊人地揭示了这些酶调控的原子基础，并为理解CDK家族其他成员的功能和调控提供了一个模板。
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