使用十进制分析法评估相加性，以证明体外酮康唑、多氧霉素Z和布洛芬对白色念珠菌的联合组合具有协同作用。
Use of decimal assay for additivity to demonstrate synergy in pair combinations of econazole, nikkomycin Z, and ibuprofen against Candida albicans in vitro.
作者信息
Tariq V N, Scott E M, McCain N E
机构信息
School of Biology and Biochemistry, Queen's University of Belfast, Northern Ireland, United Kingdom.
出版信息
Antimicrob Agents Chemother. 1995 Dec;39(12):2615-9. doi: 10.1128/AAC.39.12.2615.
Abstract
Interactions between six compounds (econazole, miconazole, amphotericin B, nystatin, nikkomycin Z, and ibuprofen) were investigated for their antifungal activities against Candida albicans by using pair combinations in an in vitro decimal assay for additivity based on disk diffusion. Additive interactions were observed between miconazole and econazole, amphotericin B and nystatin, and amphotericin B and ibuprofen, while an antagonistic interaction was observed between econazole and amphotericin B. Synergistic interactions were recorded for the combinations of econazole and ibuprofen, econazole and nikkomycin Z, and ibuprofen and nikkomycin Z.
摘要
通过在基于纸片扩散法的体外十进制加和性试验中采用配对组合，研究了六种化合物（益康唑、咪康唑、两性霉素B、制霉菌素、多氧霉素Z和布洛芬）对白色念珠菌的抗真菌活性之间的相互作用。观察到咪康唑与益康唑、两性霉素B与制霉菌素以及两性霉素B与布洛芬之间存在相加相互作用，而益康唑与两性霉素B之间存在拮抗相互作用。记录到益康唑与布洛芬、益康唑与多氧霉素Z以及布洛芬与多氧霉素Z的组合存在协同相互作用。
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