[采用ATB真菌法评估A型和B型白色念珠菌临床分离株对抗真菌药物的敏感性]
[Assessment of the sensitivity to antifungal agents of clinical isolates of Candida albicans serotype A and B by the ATB Fungus method].
作者信息
Quindós G, San Millán R, Burgos A, Lipperheide V, Tellaetxe M, Alonso R, Barturen B, Pontón J
机构信息
Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Odontología, Universidad del País Vasco, Bilbao.
出版信息
Enferm Infecc Microbiol Clin. 1995 Apr;13(4):209-12.
BACKGROUND
Candida albicans is the most frequently species isolated in patients with candidiasis. This species may be antigenically divided in serotypes A and B, which have a different pathogenic behavior and antifungal susceptibility pattern.
METHODS
The antifungal susceptibility of 443 clinical isolates from both serotypes of C. albicans to 5-fluorocytosine (5FC), amphotericin B, nystatin, econazole, miconazole and ketoconazole has been tested by means of the ATB Fungus method.
RESULTS
Both serotypes showed a similar in vitro susceptibility to amphotericin B, nystatin, econazole, miconazole and ketoconazole. All the isolates were susceptible to amphotericin B and nystatin. A small number of in vitro resistant isolates were observed to azole compounds. However, serotype B was significantly more resistant than serotype A (p = 0.0001) to 5FC.
CONCLUSIONS
C. albicans serotype B shows a lower susceptibility than serotype A to 5FC, an antifungal product not marketed in Spain. Serotyping of C. albicans does not offer additional information on antifungal susceptibility of clinical isolates from this species.
背景
白色念珠菌是念珠菌病患者中最常分离出的菌种。该菌种在抗原性上可分为A和B血清型，它们具有不同的致病行为和抗真菌药敏模式。
方法
采用ATB真菌法检测了443株来自白色念珠菌两种血清型的临床分离株对5-氟胞嘧啶（5FC）、两性霉素B、制霉菌素、益康唑、咪康唑和酮康唑的抗真菌药敏情况。
结果
两种血清型对两性霉素B、制霉菌素、益康唑、咪康唑和酮康唑显示出相似的体外药敏性。所有分离株对两性霉素B和制霉菌素敏感。观察到少数分离株对唑类化合物体外耐药。然而，B血清型对5FC的耐药性显著高于A血清型（p = 0.0001）。
结论
白色念珠菌B血清型对5FC（一种在西班牙未上市的抗真菌产品）的敏感性低于A血清型。白色念珠菌血清分型并未提供关于该菌种临床分离株抗真菌药敏性的额外信息。
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