青霉素G与庆大霉素联合使用对耐青霉素的草绿色链球菌的活性增强。
Enhanced activity of the combination of penicillin G and gentamicin against penicillin-resistant viridans group streptococci.
作者信息
Cercenado E, Díaz M D, Sánchez-Carrillo C, Vicente T, Bernaldo de Quirós J C
机构信息
Servicio de Microbiología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
出版信息
Antimicrob Agents Chemother. 1995 Dec;39(12):2816-8. doi: 10.1128/AAC.39.12.2816.
Abstract
We evaluated the effects of the combination of penicillin G and gentamicin against 10 penicillin-resistant bacteremic isolates of viridans group streptococci for which the MICs of penicillin were 4 to 64 micrograms/ml. In time-kill studies, the combination resulted in more killing of eight isolates for which the MICs of penicillin were from 8 to 64 micrograms/ml than any of the antimicrobial agents tested alone. In general, clearly enhanced antimicrobial activity was observed with the combination.
摘要
我们评估了青霉素G与庆大霉素联合使用对10株耐青霉素的草绿色链球菌血流感染分离株的效果，这些分离株的青霉素最低抑菌浓度（MIC）为4至64微克/毫升。在时间杀菌研究中，对于青霉素MIC为8至64微克/毫升的8株分离株，联合用药比单独使用任何一种抗菌药物导致的细菌杀灭更多。总体而言，联合用药观察到明显增强的抗菌活性。
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本文引用的文献
1
Susceptibility of alpha-haemolytic streptococci causing endocarditis to benzylpenicillin and ten cephalosporins.
J Antimicrob Chemother. 1993 Jul;32(1):63-9. doi: 10.1093/jac/32.1.63.
2
Chromosomally mediated high-level gentamicin resistance in Streptococcus mitis.
Antimicrob Agents Chemother. 1993 Dec;37(12):2740-2. doi: 10.1128/AAC.37.12.2740.
3
Prevalence of penicillin-resistant viridans streptococci in healthy children and in patients with malignant haematological disorders.
Eur J Clin Microbiol Infect Dis. 1994 Aug;13(8):645-50. doi: 10.1007/BF01973990.
4
Susceptibility of enterococci and Listeria monocytogenes to N-Formimidoyl thienamycin alone and in combination with an aminoglycoside.
Antimicrob Agents Chemother. 1981 May;19(5):789-93. doi: 10.1128/AAC.19.5.789.
5
Resistance to penicillin-streptomycin synergy among clinical isolates of viridans streptococci.
Antimicrob Agents Chemother. 1983 Dec;24(6):871-5. doi: 10.1128/AAC.24.6.871.
6
Penicillin-sensitive streptococcal endocarditis. In-vitro and clinical observations on penicillin-streptomycin therapy.
Ann Intern Med. 1974 Aug;81(2):178-81. doi: 10.7326/0003-4819-81-2-178.
7
[Sensitivity of the genus Streptococcus to 9 antibiotics].
Med Clin (Barc). 1985 May 18;84(19):769-71.
8
Concomitant high-level vancomycin and penicillin resistance in clinical isolates of enterococci.
Clin Infect Dis. 1992 Mar;14(3):655-61. doi: 10.1093/clinids/14.3.655.
9
In vitro antimicrobial susceptibility of viridans streptococci isolated from blood cultures.
Eur J Clin Microbiol Infect Dis. 1992 Jun;11(6):543-6. doi: 10.1007/BF01960811.
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