Potgieter E, Carmichael M, Koornhof H J, Chalkley L J
Emergent Pathogen Research Unit, South African Medical Research Council, School of Pathology, University of the Witwatersand, Parktown, Johannesburg.
Eur J Clin Microbiol Infect Dis. 1992 Jun;11(6):543-6. doi: 10.1007/BF01960811.
The susceptibility of 211 viridans streptococci isolated from blood cultures to eight antimicrobial agents was determined. All the isolates were susceptible to cefotaxime, ceftriaxone, imipenem and vancomycin. Thirty eight percent of the isolates were resistant to penicillin (MICs greater than or equal to 0.25 micrograms/ml). Tetracycline resistance was found in 41% of the isolates and in 7% of these strains tetracycline resistance was combined with erythromycin resistance. Five Streptococcus mitis isolates exhibited increased (MIC 64 micrograms/ml and 128 micrograms/ml) or high-level (MIC greater than or equal to 500 micrograms/ml) resistance to gentamicin, kanamycin and tobramycin. Four of these isolates were also resistant to penicillin (MICs 16-32 micrograms/m). In vitro synergy was not demonstrated for combinations of penicillin and gentamicin against three Streptococcus mitis isolates with gentamicin MICs of 1000, 128 and 64 micrograms/ml. Results of this study indicate the importance of monitoring antibiotic resistance trends in viridans streptococci particularly with respect to penicillin and aminoglycoside resistance.
测定了从血培养中分离出的211株草绿色链球菌对8种抗菌药物的敏感性。所有分离株对头孢噻肟、头孢曲松、亚胺培南和万古霉素敏感。38%的分离株对青霉素耐药（最低抑菌浓度大于或等于0.25微克/毫升）。41%的分离株对四环素耐药，其中7%的菌株对四环素耐药并伴有对红霉素耐药。5株缓症链球菌分离株对庆大霉素、卡那霉素和妥布霉素表现出增加（最低抑菌浓度为64微克/毫升和128微克/毫升）或高水平（最低抑菌浓度大于或等于500微克/毫升）耐药。其中4株分离株也对青霉素耐药（最低抑菌浓度为16 - 32微克/毫升）。对于青霉素和庆大霉素联合用于3株最低抑菌浓度分别为1000、128和64微克/毫升的缓症链球菌分离株，未显示体外协同作用。本研究结果表明监测草绿色链球菌抗生素耐药趋势的重要性，尤其是对青霉素和氨基糖苷类耐药方面。
