Schmidt E V
MGH Cancer Center, Charlestown 02129, USA.
Bioessays. 1996 Jan;18(1):6-8. doi: 10.1002/bies.950180104.
Two recent reports of mice homozygously deleted for cyclin D1 provide unequivocal evidence that the critical G1 cyclin, cyclin D1, is by itself rate-limiting for growth in some mammalian tissues. Cyclin D1 knockout mice are small and exhibit behavioral abnormalities. Specific hypoplasias of retinal and mammary tissues suggest an unusual dependence on cyclin D1 function for tissue growth in those organs. The odd coincidences that cyclin D1 functions as the retinoblastoma gene kinase, together with associations between increased cyclin D1 expression and breast cancer, suggest, but do not prove, a special function of cyclin D1 in those tissues.
最近有两份关于细胞周期蛋白D1纯合缺失小鼠的报告，提供了明确的证据表明关键的G1期细胞周期蛋白——细胞周期蛋白D1本身在某些哺乳动物组织的生长中起限速作用。细胞周期蛋白D1基因敲除小鼠体型小且表现出行为异常。视网膜和乳腺组织的特定发育不全表明这些器官的组织生长对细胞周期蛋白D1功能有异常的依赖性。细胞周期蛋白D1作为视网膜母细胞瘤基因激酶发挥作用，以及细胞周期蛋白D1表达增加与乳腺癌之间的关联，这些奇怪的巧合暗示但并未证明细胞周期蛋白D1在这些组织中有特殊功能。
