一些3,4-吡啶二甲酰胺的N-氨基烷基衍生物的合成、化学及药理学性质
Synthesis, chemical and pharmacological properties of some N-aminoalkyl derivatives of 3,4-pyridinedicarboxamides.
作者信息
Sĺadowska H, Sieklucka-Dziuba M, Semczuk A, Kleinrok Z
机构信息
Department of Chemistry of Drugs, Wroclaw University of Medicine, Poland.
出版信息
Farmaco. 1995 Nov;50(11):761-8.
PMID:8593173
Abstract
The synthesis and properties of some N-aminoalkyl derivatives of 3,4-pyridinedicarboxamides (1-15) are reported. Imide 11, containing 2-hydroxy-3-(4-phenyl-l-piperazinyl) propyl substituent at the nitrogen atom, proved to have the lowest toxicity and, at very high dosages, to be the most pharmacologically active.
摘要
报道了一些3,4-吡啶二甲酰胺的N-氨基烷基衍生物（1-15）的合成及性质。酰亚胺11在氮原子处含有2-羟基-3-（4-苯基-1-哌嗪基）丙基取代基，被证明具有最低的毒性，并且在非常高的剂量下，是药理活性最高的。
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