Synthesis, chemical and pharmacological properties of some N-aminoalkyl derivatives of 3,4-pyridinedicarboxamides.

The synthesis and properties of some N-aminoalkyl derivatives of 3,4-pyridinedicarboxamides (1-15) are reported. Imide 11, containing 2-hydroxy-3-(4-phenyl-l-piperazinyl) propyl substituent at the nitrogen atom, proved to have the lowest toxicity and, at very high dosages, to be the most pharmacologically active.