肝细胞生长因子/分散因子对人毛囊生长的影响。
The effect of hepatocyte growth factor/scatter factor on human hair follicle growth.
作者信息
Jindo T, Tsuboi R, Imai R, Takamori K, Rubin J S, Ogawa H
机构信息
Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan.
出版信息
J Dermatol Sci. 1995 Nov;10(3):229-32. doi: 10.1016/0923-1811(95)00429-v.
The effect of hepatocyte growth factor/scatter factor (HGF/SF) on human hair follicle growth was examined using a serum-free organ culture system. The DNA synthesis in human hair follicles and elongation of the hair shaft were measured subsequent to the follicle isolation and culture at 31 degrees C in 95% O2-5% CO2 for 72 h. Results showed that HGF/SF significantly increased 3H-thymidine (P < 0.001) incorporation and hair follicle length (P < 0.05). The effect of HGF/SF was dose-dependent with a maximal stimulation at 10 ng/ml.
使用无血清器官培养系统检测肝细胞生长因子/分散因子（HGF/SF）对人毛囊生长的影响。在毛囊分离后，于31℃、95% O₂ - 5% CO₂条件下培养72小时，随后测量人毛囊中的DNA合成及毛干伸长情况。结果显示，HGF/SF显著增加了³H - 胸腺嘧啶核苷的掺入量（P < 0.001）和毛囊长度（P < 0.05）。HGF/SF的作用呈剂量依赖性，在10 ng/ml时刺激作用最大。
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