Chubb I W, Pilowsky P M, Springell H J, Pollard A C
Lancet. 1979 Mar 31;1(8118):688-90. doi: 10.1016/s0140-6736(79)91145-0.
Acetylcholinesterase (AChE) activity was detected in amniotic fluid either sampled by amniocentesis at 14--23 weeks gestation or collected at normal parturition. Activity ranged from 0.2 to 8.9 u/l in the earlier samples and from 0.2 to 4.2 u/l in the later samples. Since the fetal but not the maternal serum contained AChE activity, we suggest that the AChE in the amniotic fluid is derived from the fetus. AChE is released from both neural and nonneural tissues, and the release of the enzyme from both sources may diminish as the nervous system matures. The amount of AChE found in amniotic fluid may be affected by abnormalities of the nervous system. Amniotic fluid from two fetuses with spina bifida contained AChE activity: one, with a gestational age of 21 weeks, was in the upper levels of the normal range (4.5 u/l), whereas the other, at 36 weeks, contained 1.9 times more activity than the next highest sample. In a 20-week fetus with anencephaly, the AChE activity in the amniotic fluid was increased 2.8-fold over the activity of the highest "normal" sample.
在妊娠14 - 23周通过羊膜穿刺术采集的羊水或在正常分娩时收集的羊水中检测到乙酰胆碱酯酶（AChE）活性。早期样本中的活性范围为0.2至8.9 u/l，后期样本中的活性范围为0.2至4.2 u/l。由于胎儿血清而非母体血清含有AChE活性，我们认为羊水中的AChE源自胎儿。AChE从神经组织和非神经组织中释放，随着神经系统成熟，这两种来源的酶释放量可能会减少。羊水中发现的AChE量可能受神经系统异常的影响。两名患有脊柱裂胎儿的羊水含有AChE活性：一名孕龄为21周，处于正常范围的较高水平（4.5 u/l），而另一名36周的胎儿，其活性比第二高的样本高出1.9倍。在一名20周无脑儿胎儿中，羊水中的AChE活性比最高“正常”样本的活性增加了2.8倍。
