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坏疽性脓皮病样损害:中性粒细胞减少患者播散性镰刀菌感染的一个征象。

Ecthyma gangrenosum-like lesions: a sign of disseminated Fusarium infection in the neutropenic patient.

作者信息

Prins C, Chavaz P, Tamm K, Hauser C

机构信息

Department of Dermatology, University Hospital, Geneva, Switzerland.

出版信息

Clin Exp Dermatol. 1995 Sep;20(5):428-30. doi: 10.1111/j.1365-2230.1995.tb01365.x.

Abstract

Fusarium is a saprophytic fungus of soil causing disease in plants and animals. In the immunocompetent patient, Fusarium is non-invasive, colonizing wounds, ulcers or nails. In the immunocompromised host, however, especially in those whose neutrophil and macrophage function is deficient, it can cause devastating systemic infections. Skin lesions are an early feature of the disseminated disease. Rapid diagnosis and treatment are mandatory in order to give the patient a better chance of survival, reported mortality rates being as high as 90%.

摘要

镰刀菌是一种土壤腐生真菌,可导致动植物患病。在免疫功能正常的患者中,镰刀菌是非侵袭性的,主要定植于伤口、溃疡或指甲。然而,在免疫功能低下的宿主中,尤其是中性粒细胞和巨噬细胞功能缺陷的患者,它可引起严重的全身感染。皮肤病变是播散性疾病的早期特征。为了给患者更好的生存机会,必须进行快速诊断和治疗,据报道死亡率高达90%。

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