Swick Brian L, Reddy Sindhura C, Friedrichs Amanda, Stone Mary Seabury
University of Iowa, Departments of Dermatology and Pathology, Iowa City, IA 52242, USA.
J Cutan Pathol. 2010 Jun;37(6):687-91. doi: 10.1111/j.1600-0560.2009.01358.x. Epub 2009 Jul 14.
Disseminated fungal infections are a major cause of mortality in severely immunocompromised bone marrow transplant (BMT) patients. Scopulariopsis is a soil saprophytic mould that is typically associated with onychomycosis and only rarely associated with disseminated infection with cutaneous findings. We describe a case of fatal disseminated Scopulariopsis infection in a 56-year-old neutropenic male with chronic myelogenous leukemia status post peripheral blood stem cell transplant that was clinically and histologically indistinguishable from disseminated Aspergillus, Fusarium or zygomycosis infection. Distinguishing the above listed fungi by tissue culture is crucial because disseminated Scopulariopsis is difficult to eradicate and associated with a high mortality rate in the immunocompromised BMT patient population.
播散性真菌感染是严重免疫功能低下的骨髓移植（BMT）患者死亡的主要原因。帚霉属是一种土壤腐生霉菌，通常与甲癣有关，很少与伴有皮肤表现的播散性感染有关。我们描述了一例56岁慢性粒细胞白血病中性粒细胞减少男性患者，在接受外周血干细胞移植后发生致命的播散性帚霉感染，其临床和组织学表现与播散性曲霉、镰刀菌或接合菌感染无法区分。通过组织培养区分上述真菌至关重要，因为播散性帚霉难以根除，且在免疫功能低下的BMT患者群体中死亡率很高。
