Watabe H, Itoh M, Cunningham V, Lammertsma A A, Bloomfield P, Mejia M, Fujiwara T, Jones A K, Jones T, Nakamura T
Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
J Cereb Blood Flow Metab. 1996 Mar;16(2):311-9. doi: 10.1097/00004647-199603000-00017.
This study proposes a new method for the pixel-by-pixel quantification of regional CBF (rCBF) with positron emission tomography and H(15)(2)O by using a reference tissue region. No arterial blood is required. Simulation studies revealed that the calculation of rCBF was fairly stable provided that the frame time was relatively short compared with total scan time. In practice, calculated CBF images correlated significantly with those obtained with the dynamic/integral method. Because the method accurately detects changes in CBF, it is particularly suitable for brain activation studies.
本研究提出了一种新方法，通过使用参考组织区域，利用正电子发射断层扫描和H(15)(2)O对局部脑血流量（rCBF）进行逐像素定量分析。无需动脉血。模拟研究表明，只要帧时间与总扫描时间相比相对较短，rCBF的计算就相当稳定。在实际应用中，计算得到的脑血流量图像与采用动态/积分法获得的图像显著相关。由于该方法能准确检测脑血流量的变化，因此特别适用于脑激活研究。
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