Hakim S L, Vythilingam I, Marzukhi M I, Mak J W
Institute for Medical Research, Jalan, Pahang, Kuala Lumpur, Malaysia.
Trans R Soc Trop Med Hyg. 1995 Nov-Dec;89(6):686-9. doi: 10.1016/0035-9203(95)90445-x.
The study compared the effectiveness of a single dose of diethylcarbamazine (DEC) (6mg/kg) with the standard regimen of 6 doses (total 36 mg/kg) in mass chemotherapy for the control of brugian filariasis. Mass chemotherapy with single-dose DEC was instituted in one area and standard dose in the other and treatment was repeated after one year. Parasitological surveys were conducted before, and 3, 7 and 12 months after treatment. Pretreatment characteristics were not significantly different between the 2 treatment areas. There was a significant reduction in microfilaraemia prevalence rate from 24.7% to 14.7% at 12 months and to 6.8% at 19 months in the single dose area and from 22.8% to 9.6% at 12 months and to 2.7% at 19 months with the standard dose. Maximum reduction was at 7 months after treatment with both regimens. There was also significant progressive reduction in mean microfilarial density from 4.39 +/- 20.37 to 0.89 +/- 4.16 per 60 microL in the single-dose area and from 4.43 +/- 17.31 to 0.75 +/- per 60 microL in the standard dose area. There was a greater reduction of both microfilarial prevalence and density using the standard regimen but it was not statistically significant. Thus, a single dose of DEC is as effective as the standard dose in controlling periodic brugian filariasis.
该研究比较了单剂量乙胺嗪（DEC）（6毫克/千克）与6剂标准方案（总量36毫克/千克）在大规模化疗中控制布鲁氏丝虫病的效果。在一个地区采用单剂量DEC进行大规模化疗，在另一个地区采用标准剂量，并在一年后重复治疗。在治疗前、治疗后3个月、7个月和12个月进行寄生虫学调查。两个治疗地区的治疗前特征无显著差异。单剂量地区微丝蚴血症患病率在12个月时从24.7%显著降至14.7%，在19个月时降至6.8%；标准剂量地区在12个月时从22.8%降至9.6%，在19个月时降至2.7%。两种方案治疗后7个月时降低幅度最大。单剂量地区每60微升平均微丝蚴密度也从4.39±20.37显著降至0.89±4.16，标准剂量地区从4.43±17.31降至0.75±。使用标准方案时微丝蚴患病率和密度的降低幅度更大，但无统计学意义。因此，单剂量DEC在控制周期性布鲁氏丝虫病方面与标准剂量同样有效。
