Long-lasting antagonistic effects of monatepil on Ca2+ current in guinea-pig ventricular cells.
作者信息
Nagata S, Hosoki K, Karasawa T
机构信息
Department of Pharmacology I, Dainippon Pharmaceutical Co., Ltd., Osaka, Japan.
出版信息
Arzneimittelforschung. 1995 Oct;45(10):1061-3.
PMID:8595058
Abstract
Monatepil maleate (CAS 103377-41-9, AJ-2615), a new derivative of dihydrodibenzothiepins, showed dose-dependent inhibition of Ca2+ current (ICa) in single cardiac cells isolated from guinea-pig ventricle. ICa was elicited by depolarization from -40 mV to +10 mV at 0.2 Hz. IC50 value of monatepil for the peak ICa at +10 mV was 18.7 nmol/l. The ICa inhibition was still sustained 30 min after washout, indicating that monatepil had long lasting activity in the mammalian single muscle cell.
摘要
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