Rogers R F, Matzel L D
Department of Psychology, Rutgers University, New Brunswick, New Jersey 08903, USA.
Neuroreport. 1995 Nov 13;6(16):2161-5. doi: 10.1097/00001756-199511000-00016.
A G-protein dependent serotonin (5-HT) receptor on B photoreceptors of Hermissenda crassicornis was investigated. Microapplication of 5-HT to the soma region, but not to the terminal branches, resulted in a rapid, biphasic depolarization with a slow time course of dissipation. The 5-HT-induced depolarization increased at hyperpolarized potentials, and exhibited a strong and complex sensitivity to external K+, but not Na+ or Ca2+. The 5-HT response, but not a cholinergically mediated intraphotoreceptor interaction, was abolished by intracellular injection of the G protein antagonist, GDP[beta S], although the response was unaffected by pretreatment with pertussis toxin. These results are discussed in terms of known 5-HT receptor subtypes, and the potential role of this receptor in activity-dependent forms of plasticity exhibited by these cells.
对肥大海兔（Hermissenda crassicornis）B光感受器上一种G蛋白依赖性5-羟色胺（5-HT）受体进行了研究。将5-HT微量施加于细胞体区域而非终末分支时，会导致快速的双相去极化，且消散时间进程缓慢。5-HT诱导的去极化在超极化电位时增强，并且对外部K +表现出强烈而复杂的敏感性，但对Na +或Ca2 +不敏感。通过细胞内注射G蛋白拮抗剂GDP[βS]可消除5-HT反应，但胆碱能介导的光感受器内相互作用不受影响，尽管该反应不受百日咳毒素预处理的影响。根据已知的5-HT受体亚型对这些结果进行了讨论，以及该受体在这些细胞表现出的活性依赖性可塑性形式中的潜在作用。
