黑皮质素1受体在中脑导水管周围灰质中的表达。
Expression of melanocortin 1 receptor in periaqueductal gray matter.
作者信息
Xia Y, Wikberg J E, Chhajlani V
机构信息
Department of Pharmaceutical Biosciences, Uppsala University, Sweden.
出版信息
Neuroreport. 1995 Nov 13;6(16):2193-6. doi: 10.1097/00001756-199511000-00022.
The localization of the melanocortin 1 (MC1) receptor in brain was investigated by in situ hybridization and immunohistochemistry. In rat periaqueductal gray matter (PAG), a small number of cells which displayed a punctate distribution showed a specific hybridization signal for MC1 receptor mRNA, whereas other regions studied were negative. In human PAG, the immunoreactivity for MC1 receptor was detected in scattered cells. These results indicate that a restricted distribution of MC1 receptor is present in the central nervous system.
通过原位杂交和免疫组织化学方法研究了黑皮质素1（MC1）受体在脑中的定位。在大鼠中脑导水管周围灰质（PAG）中，少数呈点状分布的细胞显示出MC1受体mRNA的特异性杂交信号，而其他研究区域为阴性。在人类PAG中，在散在细胞中检测到MC1受体的免疫反应性。这些结果表明，MC1受体在中枢神经系统中呈局限性分布。
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