Celenza A, Fothergill J, Kupek E, Shaw R J
St Mary's Hospital, London.
BMJ. 1996 Mar 9;312(7031):604-7. doi: 10.1136/bmj.312.7031.604.
To seek associations between meteorological factors, concentrations of air pollutants or pollen, and an asthma epidemic which occurred in London on 24 and 25 June 1994 after a thunderstorm.
Retrospective study of patients' accident and emergency department records, with bivariate and multivariate analysis of environmental factors and data collection for the two months surrounding the epidemic.
The accident and emergency department of St Mary's Hospital in west central London.
148 patients presenting with asthma between 1 June and 31 July 1994, of whom 40 presented in the 24 hours after the storm.
The asthma epidemic was significantly associated with a drop in air temperature six hours previously and a high grass pollen concentration nine hours previously. Non-epidemic asthma was significantly associated with lightning strikes, increase in humidity or sulphur dioxide concentration, a drop in temperature or high rainfall the previous day, and a decrease in maximum air pressure or changes in grass pollen counts over the previous two days.
New episodes of asthma during the epidemic on 24 and 25 June 1994 were associated with a fall in air temperature and a rise in grass pollen concentration. Non-epidemic asthma was significantly associated with a greater number of environmental changes. This may indicate that the patients with thunderstorm associated asthma were a separate population, sensitive to different environmental stimuli.
探寻气象因素、空气污染物浓度或花粉浓度与1994年6月24日和25日一场雷雨后伦敦发生的哮喘流行之间的关联。
对患者急诊记录进行回顾性研究，对环境因素进行双变量和多变量分析，并收集流行发生前两个月及后两个月的数据。
伦敦市中心西部的圣玛丽医院急诊科。
1994年6月1日至7月31日期间因哮喘前来就诊的148例患者，其中40例在风暴后的24小时内就诊。
哮喘流行与6小时前气温下降及9小时前高浓度的草花粉显著相关。非流行期哮喘与雷击、湿度增加或二氧化硫浓度升高、前一天气温下降或降雨量大以及前两日最高气压下降或草花粉计数变化显著相关。
1994年6月24日和25日流行期间哮喘新发病例与气温下降和草花粉浓度升高有关。非流行期哮喘与更多的环境变化显著相关。这可能表明与雷暴相关的哮喘患者是一个独立群体，对不同的环境刺激敏感。
