Achtani C, Awtade A, Vasisht S, Srivastava L M
Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
Biochem Mol Biol Int. 1995 Oct;37(3):489-98.
The effect of dietary MaxEPA (fish oil) supplementation on cholesterol induced hypercholesterolemia in rabbits was investigated. Rabbits were fed 0.1% cholesterol enriched diet for one month and randomly divided into two groups (I and II). Group I was continued on a 0.1% cholesterol rich diet whereas group II in addition to cholesterol supplementation received MaxEPA (2.5 g/kg body weight) per day for a period of two months. B-VLDL-C, LDL-C and total serum peroxide levels (TBARS) were significantly higher in group II animals as compared to group I. No statistical difference was found in the number of hepatic B-VLDL binding sites between group I and II. Microscopic examination of the aorta showed an increase in the number of intimal foam cells in MaxEPA treated group, a result that may be linked to increase in total cholesterol, plasma TBARS and with simultaneous reduced hepatic uptake of B-VLDL.
研究了膳食补充MaxEPA（鱼油）对胆固醇诱导的家兔高胆固醇血症的影响。家兔喂食富含0.1%胆固醇的饲料一个月，然后随机分为两组（I组和II组）。I组继续喂食富含0.1%胆固醇的饲料，而II组除补充胆固醇外，每天还接受MaxEPA（2.5克/千克体重），持续两个月。与I组相比，II组动物的B-VLDL-C、LDL-C和总血清过氧化物水平（TBARS）显著更高。I组和II组之间肝B-VLDL结合位点的数量没有统计学差异。主动脉的显微镜检查显示，MaxEPA处理组的内膜泡沫细胞数量增加，这一结果可能与总胆固醇、血浆TBARS的增加以及同时肝脏对B-VLDL摄取的减少有关。
