Muldoon M F, Waldstein S R, Jennings J R
University of Pittsburgh School of Medicine, Pennsylvania, USA.
Exp Aging Res. 1995 Oct-Dec;21(4):353-68. doi: 10.1080/03610739508253990.
A growing proportion of the general population is being prescribed antihypertensive medications for the long-term treatment of essential hypertension. Untreated hypertensive individuals exhibit some neuropsychological performance decrements, and numerous researchers have sought to determine whether drug therapy for hypertension worsens, improves, or leaves unaltered objectively measured cognitive skills. These issues may be especially important in the elderly, among whom both high blood pressure and compromised cognitive function are common. In this review, we collate the findings of more than 50 clinical studies according to class of antihypertensive medication studied and domains of neuropsychological performance assessed. Special attention is given to investigations of elderly subjects, and a critical summary is provided.
越来越多的普通人群正在接受抗高血压药物治疗，以长期治疗原发性高血压。未经治疗的高血压患者表现出一些神经心理功能下降，许多研究人员试图确定高血压药物治疗是否会使客观测量的认知技能恶化、改善或保持不变。这些问题在老年人中可能尤为重要，因为高血压和认知功能受损在老年人中都很常见。在本综述中，我们根据所研究的抗高血压药物类别和所评估的神经心理功能领域，整理了50多项临床研究的结果。我们特别关注对老年受试者的调查，并提供了一个批判性的总结。
