Burton P R, Draper E, Fenton A, Field D
T V W Telethon Institute of Child Health Research, West Perth, Australia.
J Epidemiol Community Health. 1995 Dec;49(6):617-28. doi: 10.1136/jech.49.6.617.
To estimate the population based requirement for neonatal intensive care (NIC) cots by investigating NIC utilisation in a large population based study.
This was a two year, non-randomised, prospective cohort study of neonates receiving NIC in hospitals in the Trent Regional Health Authority (RHA).
The main study considered the 2979 neonates born to Trent RHA residents who had begun high dependency care in Trent RHA or neighbouring health authorities between 1 April 1990 and 31 March 1992 and met any of the following criteria: (i) birth weight < 1500 g; (ii) gestation < 32 weeks; (iii) need for active respiratory support other than initial resuscitation; (iv) need for in utero or neonatal transfer to receive high dependency care; (v) severe asphyxial brain insult after delivery : and (vi) death. The analysis here is restricted to the 1730 neonates who received total parenteral nutrition or assisted ventilation, or both; that is, those who received NIC level 1 (ICL1) on at least one day. MEASUREMENT AND ANALYSIS: The treatment history of each neonate was converted into a time-line detailing the dates of beginning and stopping NIC, the dates of any transfers between units, and any gaps in NIC treatment. The duration of ICL1 was observed directly and that of intensive care level 2 (ICL20 was imputed from a model based upon round trip transfers. These were also recorded on the timeline. The time-lines were first used to derived the observed distribution of the utilisation of NIC cots in Trent RHA during the study. An extensive series of Monte Carlo simulations was then carried out in order; (i) to estimate cot requirements in smaller populations; (ii) to determine whether Trent RHA utilised its NIC cots in a manner that was clinically appropriate at the population based level; (iii) to perform a series of sensitivity analyses; and (iv) to compare results with an equivalent study carried out in the Northern RHA.
Trent RHA is reasonably representative of the greater population of England and Wales in terms of both the distribution of birth weight and of birth weight-specific neonatal mortality. Trent RHA did not seen to be underprovided for NIC cots or to be overusing these cots inappropriately. It therefore seems reasonable, if the assumptions of the analysis are borne carefully in mind, to treat these utilisation data as a rough guide to true population based need. NIC cot requirements depend critically upon the size of the served population - small populations are subject to greater random variability and require relatively more cots to ensure cot availability on an equivalent proportion of days. A neonatal unit should not therefore serve a population generating fewer than 5000 and 25 000 births per annum, the estimated population based provision which would ensure free cots on 29 out of 30 days falls gradually from 1.20 to 0.88 NIC cots per 1000 births per annum. A cooperative network of NICUs offers the opportunity to provide fewer cots per head of population while maintaining good access for most neonates referred to the service.
通过在一项基于大人群的研究中调查新生儿重症监护(NIC)床位的使用情况,估算基于人群的新生儿重症监护床位需求。
这是一项为期两年的非随机前瞻性队列研究,研究对象为在特伦特地区卫生局(RHA)各医院接受NIC治疗的新生儿。
主要研究纳入了1990年4月1日至1992年3月31日期间在特伦特RHA或邻近卫生局开始接受高度依赖护理的特伦特RHA居民所生的2979例新生儿,这些新生儿符合以下任何一项标准:(i)出生体重<1500 g;(ii)孕周<32周;(iii)除初始复苏外需要积极的呼吸支持;(iv)需要宫内或新生儿转运以接受高度依赖护理;(v)出生后严重窒息性脑损伤;以及(vi)死亡。此处的分析仅限于1730例接受了全胃肠外营养或辅助通气,或两者皆有的新生儿;即至少有一天接受了NIC 1级(ICL1)护理的新生儿。测量与分析:将每个新生儿的治疗史转换为时间线,详细列出开始和停止NIC的日期、各单位之间的任何转运日期以及NIC治疗中的任何间隔。直接观察ICL1的持续时间,而重症监护2级(ICL2)的持续时间则根据基于往返转运的模型进行估算。这些也记录在时间线上。时间线首先用于得出研究期间特伦特RHA中NIC床位使用情况的观察分布。然后进行了一系列广泛的蒙特卡罗模拟,目的如下:(i)估算较小人群的床位需求;(ii)确定特伦特RHA使用其NIC床位的方式在基于人群的层面上是否在临床上合适;(iii)进行一系列敏感性分析;以及(iv)将结果与在北部RHA进行的一项等效研究进行比较。
就出生体重分布和特定出生体重的新生儿死亡率而言,特伦特RHA在很大程度上代表了英格兰和威尔士的总体人群。特伦特RHA似乎既没有NIC床位供应不足,也没有不适当地过度使用这些床位。因此,如果仔细牢记分析的假设,将这些使用数据视为基于真实人群需求的粗略指南似乎是合理的。NIC床位需求严重取决于所服务人群的规模——较小的人群面临更大的随机变异性,并且需要相对更多的床位以确保在相当比例的天数内有床位可用。因此,一个新生儿病房服务的人群每年出生数不应少于5000例和25000例,基于人群的估计供应量,即确保30天中有29天有免费床位,每年每1000例出生的NIC床位数从1.20逐渐降至0.88。新生儿重症监护病房的合作网络提供了机会,在为大多数转诊到该服务的新生儿保持良好可及性的同时,减少人均床位数量。