[乙酰胆碱和解胆碱药对环层小体活性的影响]
[Effect of acetylcholine and cholinolytics on the activity of Pacinian corpuscles].
作者信息
Akoev G N, Chelyshev Iu A
出版信息
Neirofiziologiia. 1977;9(2):185-90.
The effect of acetylcholine and cholinergic antagonists (atropine, d-tubocurarine, hexamethonium) was studied as applied to isolated decapsulated preparations. Acetylcholine (10(-5)-10(-4) g/ml) enhanced the sensitivity of the receptors to mechanical stimuli due to increased excitability of the Ranvier node. The amplitude of the receptor potential decreased. Cholinergic drugs did not block the responses of receptors to mechanical stimuli. The results provide evidence against the role of acetylcholine as a transmitter in the Pacinian corpuscles.
研究了乙酰胆碱和胆碱能拮抗剂（阿托品、d - 筒箭毒碱、六甲铵）应用于离体去包膜制剂时的作用。乙酰胆碱（10⁻⁵ - 10⁻⁴ g/ml）由于郎飞结兴奋性增加而增强了感受器对机械刺激的敏感性。感受器电位的幅度降低。胆碱能药物并未阻断感受器对机械刺激的反应。这些结果提供了反对乙酰胆碱作为环层小体中递质作用的证据。
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