Axelrod J D, Matsuno K, Artavanis-Tsakonas S, Perrimon N
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Science. 1996 Mar 29;271(5257):1826-32. doi: 10.1126/science.271.5257.1826.
In Drosophila, the Wingless and Notch signaling pathways function in m any of the same developmental patterning events. Genetic analysis demonstrates that the dishevelled gene, which encodes a molecule previously implicated in implementation of the Winglass signal, interacts antagonistically with Notch and one of its known ligands, Delta. A direct physical interaction between Dishevelled and the Notch carboxyl terminus, distal to the cdc10/ankyrin repeats, suggests a mechanism for this interaction. It is proposed that Dishevelled, in addition to transducing the Wingless signal, blocks Notch signaling directly, thus providing a molecular mechanism for the inhibitory cross talk observed between these pathways.
在果蝇中，无翅（Wingless）信号通路和Notch信号通路在许多相同的发育模式形成事件中发挥作用。遗传分析表明，编码一种先前被认为参与无翅信号传导的分子的蓬乱（dishevelled）基因，与Notch及其已知配体之一Delta发生拮抗相互作用。蓬乱蛋白与Notch羧基末端（位于cdc10/锚蛋白重复序列远端）之间的直接物理相互作用，提示了这种相互作用的机制。有人提出，蓬乱蛋白除了转导无翅信号外，还直接阻断Notch信号传导，从而为这些信号通路之间观察到的抑制性相互作用提供了一种分子机制。
