Miller F J
Chemical Industry Institute of Toxicology, Research Triangle Park, NC 27709, USA.
Toxicol Lett. 1995 Dec;82-83:277-85. doi: 10.1016/0378-4274(95)03562-1.
Ozone (O3) is a ubiquitous pollutant with an array of established effects following acute and chronic exposure. Absorption of O3 occurs in all regions of the respiratory tract, but injury to the pulmonary region appears to be of greatest concern because of the susceptibility of this region to the development of chronic disease. Processes that affect the uptake and transport of O3 and available dosimetry models are briefly reviewed prior to discussing recent experimental dosimetry data in laboratory animals and humans. Dosimetry model predictions are compared with experimental data, and an example is provided that illustrates the potential for such models to contribute to our understanding of toxicological results.
臭氧（O₃）是一种普遍存在的污染物，急性和慢性暴露后会产生一系列既定影响。呼吸道的所有区域都会吸收O₃，但肺部区域的损伤似乎最令人担忧，因为该区域易患慢性病。在讨论实验室动物和人类的近期实验剂量学数据之前，简要回顾了影响O₃摄取和传输的过程以及可用的剂量学模型。将剂量学模型预测与实验数据进行比较，并提供一个示例来说明此类模型有助于我们理解毒理学结果的潜力。
