Král H, Hamet A, Cernohorský D, Stásek J, Tilser P
2nd Department of Medicine, Charle's University, Hradec Králové.
Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove. 1993;36(4-5):317-24.
The haemodynamic response to oxygen breathing and various vasodilatory drugs (Nifedipine, Ketanserin, Dihydralazine, Nitroglycerin, Iso-Mack, Nit-Ret) was repeatedly measured at different time intervals (4-24 months) in 10 males with hypoxic pulmonary hypertension due to chronic obstructive lung disease. It was found that the pulmonary artery mean pressure and pulmonary vascular resistance changes are stable in most of the patients, discordant reactions being exceptional and of small degree. The authors consider these findings important in the therapeutical decision making for longterm oxygen therapy and or vasodilatory drug administration.
在10名因慢性阻塞性肺疾病导致低氧性肺动脉高压的男性患者中，于不同时间间隔（4 - 24个月）反复测量了对吸氧及各种血管扩张药物（硝苯地平、酮色林、双肼屈嗪、硝酸甘油、异山梨酯、硝酸异山梨醇酯）的血流动力学反应。结果发现，大多数患者的肺动脉平均压和肺血管阻力变化稳定，不一致的反应罕见且程度轻微。作者认为这些发现对于长期氧疗和/或血管扩张药物给药的治疗决策具有重要意义。
