Schatz G, Dobberstein B
Biozentrum der Universität Basel, Switzerland.
Science. 1996 Mar 15;271(5255):1519-26. doi: 10.1126/science.271.5255.1519.
Most major systems that transport proteins across a membrane share the following features: an amino-terminal transient signal sequence on the transported protein, a targeting system on the cis side of the membrane, a hetero-oligomeric transmembrane channel that is gated both across and within the plane of the membrane, a peripherally attached protein translocation motor that is powered by the hydrolysis of nucleoside triphosphate, and a protein folding system on the trans side of the membrane. These transport systems are divided into two families: export systems that export proteins out of the cytosol, and import systems that transport proteins into cytosol-like compartments.
被转运蛋白质上的氨基末端瞬时信号序列、膜顺式侧的靶向系统、跨膜且在膜平面内均受门控的异源寡聚跨膜通道、由核苷三磷酸水解供能的外周附着的蛋白质转运马达，以及膜反式侧的蛋白质折叠系统。这些转运系统分为两个家族：将蛋白质输出胞质溶胶的输出系统，以及将蛋白质转运到类胞质溶胶区室的输入系统。
