Vallee R B, Sheetz M P
Worcester Foundation for Biomedical Research, Shrewsbury, MA 01545, USA.
Science. 1996 Mar 15;271(5255):1539-44. doi: 10.1126/science.271.5255.1539.
Microtubules are responsible for chromosome segregation and the movement and reorganization of membranous organelles. Many aspects of microtubule-based motility can be attributed to the action of motor proteins, producing force directed toward either end of microtubules. How these proteins are targeted to the appropriate organellar sites within the cell, however, has remained a mystery. Recent work has begun to define the targeting mechanism for two well-studied motor proteins, kinesin and cytoplasmic dynein.
微管负责染色体分离以及膜性细胞器的移动和重组。基于微管的运动的许多方面可归因于驱动蛋白的作用，产生朝向微管两端的力。然而，这些蛋白质如何靶向细胞内合适的细胞器位点仍是个谜。最近的研究已开始明确两种经过充分研究的驱动蛋白——驱动蛋白和胞质动力蛋白的靶向机制。
