Perelson A S, Neumann A U, Markowitz M, Leonard J M, Ho D D
Theoretical Division, Los Alamos National Laboratory, NM 87545, USA.
Science. 1996 Mar 15;271(5255):1582-6. doi: 10.1126/science.271.5255.1582.
A new mathematical model was used to analyze a detailed set of human immunodeficiency virus-type 1 (HIV-1) viral load data collected from five infected individuals after the administration of a potent inhibitor of HIV-1 protease. Productively infected cells were estimated to have, on average, a life-span of 2.2 days (half-life t 1/2 = 1.6 days), and plasma virions were estimated to have a mean life-span of 0.3 days (t 1/2 = 0.24 days). The estimated average total HIV-1 production was 10.3 x 10(9) virions per day, which is substantially greater than previous minimum estimates. The results also suggest that the minimum duration of the HIV-1 life cycle in vivo is 1.2 days on average, and that the average HIV-1 generation time--defined as the time from release of a virion until it infects another cell and causes the release of a new generation of viral particles--is 2.6 days. These findings on viral dynamics provide not only a kinetic picture of HIV-1 pathogenesis, but also theoretical principles to guide the development of treatment strategies.
一种新的数学模型被用于分析从五名感染个体在服用一种强效HIV-1蛋白酶抑制剂后收集的一组详细的1型人类免疫缺陷病毒（HIV-1）病毒载量数据。据估计，有 productive 感染的细胞平均寿命为2.2天（半衰期t 1/2 = 1.6天），血浆病毒粒子的平均寿命估计为0.3天（t 1/2 = 0.24天）。估计的HIV-1平均总产生量为每天10.3×10(9)个病毒粒子，这大大高于先前的最低估计值。结果还表明，HIV-1在体内生命周期的最短持续时间平均为1.2天，并且HIV-1的平均世代时间（定义为从一个病毒粒子释放到它感染另一个细胞并导致新一代病毒粒子释放的时间）为2.6天。这些关于病毒动力学的发现不仅提供了HIV-1发病机制的动力学图景，还为指导治疗策略的制定提供了理论原则。 （注：原文中“Productively infected cells”直译为“有 productive 感染的细胞”，这里的“productive”在医学语境可能有特定含义，若有更准确的专业术语可替换，以保证译文更精准。）
