Ferreira L A, Möllring T, Lebrun F L, Raida M, Znottka R, Habermehl G G
Departamento de Bioquimica e Biofisica, Instituto Butantan, São Paulo, Brazil.
Toxicon. 1995 Oct;33(10):1313-9. doi: 10.1016/0041-0101(95)00071-s.
The contractile action of bradykinin on isolated smooth muscles is known to be potentiated by special peptides isolated from snake venoms and other animal sources. A fraction F (AppF) has been derived from Agkistrodon piscivorus piscivorus venom. This fraction does not increase the depressor effect of bradykinin n blood pressure, potentiates the action of bradykinin on isolated guinea-pig ileum and prolongs the duration of relaxation in isolated rat duodenum. This fraction was able to inhibit the conversion of angiotensin I to angiotensin II in vitro. The primary structure of this decapeptide is given.
已知从蛇毒和其他动物来源分离出的特殊肽可增强缓激肽对离体平滑肌的收缩作用。从食鱼蝮蛇毒中提取出了一个组分F（AppF）。该组分不会增强缓激肽对血压的降压作用，却能增强缓激肽对离体豚鼠回肠的作用，并延长离体大鼠十二指肠的舒张持续时间。该组分在体外能够抑制血管紧张素I向血管紧张素II的转化。给出了这种十肽的一级结构。
