单一元素介导HPV18的糖皮质激素反应，且与AP1或hbrm无功能相互作用。
A single element mediates glucocorticoid hormone response of HPV18 with no functional interactions with AP1 or hbrm.
作者信息
Medina-Martinez O, Morales-Peza N, Yaniv M, García-Carrancá A, Thierry F
机构信息
Departamento de Biologia Molecular, Instituto de Investigaciones Biomédicas-UNAM, Mexico.
出版信息
Virology. 1996 Mar 1;217(1):392-6. doi: 10.1006/viro.1996.0129.
We determined that the human papillomavirus type 18 (HPV18) regulatory region contains one functional GRE sequence that interacts with the glucocorticoid receptor. This sequence conferred a moderate hormonal activation to the HPV18 P105 promoter. Two modulators of glucocorticoid hormone activity, AP1 and hbrm, both involved in P105 transcription, were found not to interfere with this hormonal activation.
我们确定，18型人乳头瘤病毒（HPV18）调控区包含一个与糖皮质激素受体相互作用的功能性糖皮质激素反应元件（GRE）序列。该序列赋予HPV18 P105启动子适度的激素激活作用。发现均参与P105转录的糖皮质激素活性的两种调节剂AP1和hbrm不会干扰这种激素激活作用。
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