Jubelirer S J
Cancer Care Center of Southern West Virginia, Charleston Area Medical Center, USA.
W V Med J. 1996 Jan-Feb;92(1):26-7.
Metastatic disease to the brain occurs in 5%-10% of cases of renal cell carcinoma (RCC). Solitary involvement of the brain is less common with a reported incidence of 0.6%-2.5% in large autopsy series. In a review of the literature, only five cases of solitary brain metastasis from RCC with a latency period greater than 10 years have been documented. In this article, we report the case of an 86-year-old white female who developed a brain metastasis 15 years after nephrectomy. As a result of our experience with this patient and a review of the literature, we conclude that in patients with a history of RCC, metastatic lesions from the primary tumor must remain in the differential when evaluating any subsequent brain lesion, as metastases may appear well over a decade after nephrectomy.
脑转移瘤在5%-10%的肾细胞癌（RCC）病例中出现。脑的孤立性受累较少见，在大型尸检系列报道中，其发生率为0.6%-2.5%。在文献回顾中，仅记录了5例肾细胞癌孤立性脑转移且潜伏期超过10年的病例。在本文中，我们报告了1例86岁白人女性，其在肾切除术后15年发生脑转移。基于我们对该患者的经验及文献回顾，我们得出结论，对于有肾细胞癌病史的患者，在评估任何后续脑病变时，原发性肿瘤的转移灶必须纳入鉴别诊断，因为转移灶可能在肾切除术后十多年才出现。
